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Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease
Author(s) -
Hsu YuWen,
Lu HsingFang,
Chou WanHsuan,
Kuo HoChang,
Chang WeiChiao
Publication year - 2021
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.13381
Subject(s) - genotype , haplotype , medicine , genotyping , immunology , kawasaki disease , systemic vasculitis , cohort , vasculitis , pathogenesis , single nucleotide polymorphism , case control study , disease , gastroenterology , genetics , gene , biology , artery
Background Kawasaki disease (KD) is an acute systemic vasculitis syndrome with unknown pathogen. The immune system has been suggested to involve in the pathogenesis in KD. IP10 is a chemoattractant for initiating T‐cell activation. The aim of this study was to investigate the association between genetic polymorphisms of IP10 and KD. Methods A total of 354 KD patients and 1,709 control subjects (709 subjects in cohort 1 and 1,000 subjects in cohort 2) were enrolled in this study. Four tagging single nucleotide polymorphisms (rs3921, rs4256246, rs4508917, and rs4386624) were chosen for genotyping. Results Our results indicated that CC genotype of rs3921 and GG genotype of rs4386624 had higher frequency in KD patients compared to control. In addition, higher plasma IP10 level was observed in CC genotype of rs3921 than CG genotype and GG genotype. C/G haplotype carriers of rs3921/rs4386624 had 5.48‐fold risk for KD compared to G/C haplotype carriers. Two‐locus analysis further showed the combinatorial effects of rs3921 and rs4386624 in KD susceptibility. Conclusions This study indicated the close correlation between IP10 and the risk of Kawasaki disease.