Premium
Allergic bronchopulmonary aspergillosis in children
Author(s) -
Manti Sara,
Parisi G Fabio,
Papale Maria,
Licari Amelia,
Chiappini Elena,
Mulè Enza,
Rotolo Novella,
Leonardi Salvatore
Publication year - 2020
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.13357
Subject(s) - allergic bronchopulmonary aspergillosis , medicine , mepolizumab , omalizumab , cystic fibrosis , itraconazole , asthma , aspergillosis , aspergilloma , intensive care medicine , allergy , immunology , pediatrics , dermatology , immunoglobulin e , antibody , antifungal , eosinophil
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease caused by Aspergillus induced hypersensitivity that occurs in immunocompetent but susceptible patients with asthma and/or cystic fibrosis (CF). In children, ABPA remains mostly undiagnosed resulting in one of the most common causes of poorly controlled asthma and highly significant morbidity in children with CF. Currently, no specific diagnostic criteria of ABPA for children are available. Corticosteroids and itraconazole are the mainstays of therapy although there is a lack of randomized clinical trials regarding their usefulness for ABPA in children. Several monoclonal antibodies, such as omalizumab and mepolizumab, may be potential therapies for refractory ABPA in pediatric patients; however, further data are required to clarify the optimal dose and duration of therapy as a routine treatment approach.