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Pediatric angioedema: Essential features and preliminary results from the Hereditary Angioedema Global Registry in Italy
Author(s) -
Cancian Mauro,
Perego Francesca,
Senter Riccardo,
Arcoleo Francesco,
De Pasquale Tiziana,
Zoli Alessandra,
Cicardi Marco,
Zanichelli Andrea
Publication year - 2020
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.13170
Subject(s) - hereditary angioedema , medicine , angioedema , dermatology , population , histamine , allergy , anaphylaxis , pediatrics , immunology , environmental health
Isolated angioedema, which is a localized, non‐pitting, and transient swelling of the subcutaneous or submucosal tissue not associated with pruritus, urticaria, or anaphylaxis, may be classified, based on genetic pattern and mediators, respectively, as acquired or hereditary and histamine‐ or non‐histamine‐induced. The pediatric population with C1‐INH‐HAE (Hereditary angioedema due to C1‐inhibitor deficiency) is mostly symptomatic. The frequency of symptoms in such a population compared to adults seems to be lower, but we need more prospective data to conclude on this point. The HGR (Hereditary angioedema global registry), which collects symptoms in real time, will probably provide such information. In terms of treatments, pediatric patients are significantly disadvantaged due to the few studies aimed at registering treatment for this population.