Premium
Diagnostic approach of hypogammaglobulinemia in infancy
Author(s) -
Plebani Alessandro,
Palumbo Laura,
Dotta Laura,
Lougaris Vassilios
Publication year - 2020
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.13166
Subject(s) - hypogammaglobulinemia , medicine , iga deficiency , common variable immunodeficiency , immunology , primary immunodeficiency , immunodeficiency , antibody , immunopathology , immunoglobulin a , antibiotics , selective iga deficiency , failure to thrive , immune system , pediatrics , immunoglobulin g , microbiology and biotechnology , biology
Primary B‐cell immunodeficiency is the most frequent immune defect in infancy. Selective absence of serum and secretory immunoglobulin IgA is the most common, with rates ranging from 1/333 persons to 1/16 000, among different races. By contrast, it has been estimated that hypo/agammaglobulinemia occurs with a frequency of 1/50 000 persons. Patients with antibody deficiency are usually recognized because they have recurrent infections with encapsulated bacteria or a history of failure to respond adequately to antibiotic treatment. However, some individuals, mainly those affected by IgA deficiency (SIgAD) or transient hypogammaglobulinemia of infancy , may have few or no infections.