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Early‐life origin and prevention of chronic obstructive pulmonary diseases
Author(s) -
Moschino Laura,
Carraro Silvia,
Baraldi Eugenio
Publication year - 2020
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.13157
Subject(s) - medicine , bronchopulmonary dysplasia , rhinovirus , asthma , copd , respiratory system , genetic predisposition , pulmonary disease , disease , intensive care medicine , immunology , pediatrics , pregnancy , genetics , biology , gestational age
Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD) have their roots in the womb. Together with a genetic predisposition, prenatal and early‐life factors, including maternal smoking, prematurity, and bronchopulmonary dysplasia (BPD), have a pivotal role in later respiratory health. Then, inappropriate responses to respiratory viruses (especially respiratory syncytial virus and rhinovirus) and early allergic sensitization are the strongest contributors to the inception of wheezing and early‐onset asthma. There is an urgent need for early disease biomarkers to identify profiles at higher risk of chronic respiratory conditions. Applying the “‐omic” technologies to urine, blood and breath condensate, and non‐invasive inflammometry seem promising in this regard. The description of specific risk profiles may be the key to the use of targeted personalized therapies.