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Characteristics of NSAID ‐induced hypersensitivity reactions in childhood
Author(s) -
Cavkaytar Ozlem,
Toit George,
Caimmi Davide
Publication year - 2019
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12980
Subject(s) - medicine , anaphylaxis , disease , hypersensitivity reaction , antipyretic , epidemiology , allergy , analgesic , population , immunology , pharmacology , environmental health
Non‐steroidal anti‐inflammatory drugs ( NSAID s) are available as over‐the‐counter drugs, and they are commonly used in children for their antipyretic, analgesic, and anti‐inflammatory effects. NSAID s are among the most frequently reported drugs associated with hypersensitivity reactions and even with anaphylaxis. A complete evaluation of the patients based on reported clinical manifestations, timing of the reaction, the presence of underlying disease, and reactions to other NSAID s allows clinicians to stratify children with a history of reaction to NSAID s. Although NSAID ‐induced hypersensitivity reactions have mainly been investigated in adults, recent studies have aimed to explore their epidemiology in the pediatric population. This review will cover the current understanding of clinical manifestations, the risk factors, and the different phenotypes of NSAID ‐induced hypersensitivity reactions with a comprehensive overview of the epidemiologic data from past to present and the practical approach to the management of NSAID hypersensitivity in children and adolescents.