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Beta‐2 receptor agonist exposure in the uterus associated with subsequent risk of childhood asthma
Author(s) -
Ogawa Kohei,
Tanaka Satomi,
Limin Yang,
Arata Naoko,
Sago Haruhiko,
YamamotoHanada Kiwako,
Narita Masami,
Ohya Yukihiro
Publication year - 2017
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12805
Subject(s) - medicine , asthma , wheeze , odds ratio , in utero , pregnancy , confidence interval , confounding , offspring , cohort study , cohort , allergy , pediatrics , obstetrics , fetus , immunology , biology , genetics
Background Although the beta‐2 receptor agonist (B2 RA ) is occasionally prescribed in the prenatal period for women with preterm labor, few studies have referred to the long‐term effects of intrauterine exposure to B2 RA on fetus. We examined the association between intrauterine exposure to B2 RA and asthma in the offspring. Methods We obtained data from a hospital‐based birth cohort study conducted in Tokyo, Japan. The outcomes of interest were three indicators, consisting of current wheeze, current asthma, and ever asthma at 5 years of age, based on the International Study of Asthma and Allergies in Childhood questionnaire. Logistic regression analysis was used to evaluate the association between intrauterine B2 RA exposure and outcomes. To evaluate dose‐dependent risk, we categorized children into three groups according to both the cumulative dose and duration (days) and conducted trend analysis. Results Of 1158 children, 94 (8.1%) were exposed to B2 RA in utero, and 191 (16.5%), 111 (9.6%), and 168 (14.5%) children experienced current wheeze, current asthma, and ever asthma, respectively. After adjusting for confounders, we found an increased risk of current asthma caused by B2 RA exposure with an adjusted odds ratio of 2.04 (95% confidence interval: 1.02‐4.05). Trend analysis showed that B2 RA exposure in utero was associated with a dose‐dependent increased risk of current asthma in terms of both cumulative dose and duration ( P values for trend were .015 and .017, respectively). These results were similar to those for other outcome measures. Conclusion Exposure to B2 RA in utero could be a risk for childhood asthma.