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The relationship between anxiety and quality of life in children with hereditary angioedema
Author(s) -
Kessel Aharon,
Farkas Henriette,
Kivity Shmuel,
Veszeli Nóra,
Kőhalmi Kinga V.,
EngelYeger Batya
Publication year - 2017
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12758
Subject(s) - hereditary angioedema , medicine , anxiety , quality of life (healthcare) , state trait anxiety inventory , asymptomatic , disease , angioedema , affect (linguistics) , pediatrics , psychiatry , immunology , psychology , nursing , communication
Background The severe life‐threatening characteristics of hereditary angioedema ( HAE ) with C1‐inhibitor deficiency (C1‐ INH ‐ HAE ) can affect anxiety levels among pediatric patients. This emotional burden together with the physical restrictions of C1‐ INH ‐ HAE may decrease children's health‐related quality of life ( HRQ oL). Objectives (i) To compare anxiety state and trait between children with C1‐ INH ‐ HAE and healthy controls; (ii) to examine the relationship between the level of anxiety of children with C1‐ INH ‐ HAE , their disease activity/affected sites and their HRQ oL; and (iii) to predict the HRQ oL of children with C1‐ INH ‐ HAE based on their anxiety level and disease activity/affected sites Methods Thirty‐three children with C1‐ INH ‐ HAE (aged 5‐18 years) and 52 healthy controls were recruited from Israel and Hungary. All children completed the State‐Trait Anxiety Inventory for Children ( STAIC ), the Pediatric Quality of Life Inventory (Peds‐ QL ) demographic questionnaire and a disease activity and site questionnaire . Disease activity was defined as the number of attacks in last year. Results Both anxiety state and trait were significantly higher among children with C1‐ INH ‐ HAE as compared to the controls (44.74±10.56 vs 38.76±10.67, P <.01, 29.21±5.16 vs 25.23±4.09, P <.001 in comparison). Significant differences were found between C1‐ INH ‐ HAE patients with HAE attacks, asymptomatic C1‐ INH ‐ HAE patients, and healthy controls in both anxiety state ( F 56,2 =4.69, P =.001) and trait ( F 56,2 =9.06, P <.0001). A higher anxiety trait was correlated with the number of angioedema‐affected sites ( r =.52, P =.003). The presence of HAE attacks and higher anxiety trait predicted a lower HRQ oL in children with C1‐ INH ‐ HAE . Conclusions C1‐ INH ‐ HAE children have higher anxiety trait and state, which correlate with reduced HRQ oL domains.