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An association of periostin levels with the severity and chronicity of atopic dermatitis in children
Author(s) -
Sung Myongsoon,
Lee Kyung Suk,
Ha Eun Gyo,
Lee Seung Jin,
Kim Mi Ae,
Lee Seung Won,
Jee Hye Mi,
Sheen Youn Ho,
Jung Young Ho,
Han Man Yong
Publication year - 2017
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12744
Subject(s) - periostin , medicine , atopic dermatitis , biomarker , eosinophil , asthma , scorad , immunology , population , pathogenesis , disease , biochemistry , chemistry , environmental health , dermatology life quality index , extracellular matrix , biology , microbiology and biotechnology
Background Serum periostin might be a biomarker in the pathogenesis of T helper 2‐type allergic diseases. The aim of this study was to investigate the relationship between serum periostin levels and the severity and chronicity of atopic dermatitis ( AD ) in children. Methods This population‐based study examined 4076 children aged 4 to 13 years between June 2015 and July 2015. Of the 4076 children, 196—137 with a history of AD in the AD group and 59 without allergic diseases history in the healthy control ( HC ) group—were included for the final analysis. Results Serum periostin levels were higher in the AD group than in the HC group ( P <.001) and were found to be positively associated with SCORAD score (Spearman's rho [ r ]=.24, P =.001). Children with AD ‐onset time <2 years had significantly higher periostin levels ( P =.030) compared to those with AD ‐onset time ≥2 years. The total eosinophil ( P =.189) and IgE levels ( P =.140) were comparable between children with AD ‐onset time <2 years and those with AD ‐onset time ≥2 years. After adjustment for age, gender, and parental allergic history, serum periostin level ( OR : 1.03, 95% CI : 1.00‐1.06, P =.046) contributed to the development of AD in children with AD ‐onset time <2 years. Conclusion Serum periostin level may play a role in the severity and chronicity of AD in children.