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Nasal obstructive disorders impair health‐related quality of life in adolescents with persistent allergic rhinitis: A real‐life study
Author(s) -
VallsMateus Meritxell,
MarinoSanchez Franklin,
RuizEchevarría Karen,
CardenasEscalante Paulina,
JiménezFeijoo Rosa,
BlascoLozano Jaime,
GinerMuñoz María Teresa,
Haag Oliver,
Alobid Isam,
Plaza Martin Ana María,
Mullol Joaquim
Publication year - 2017
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12724
Subject(s) - medicine , quality of life (healthcare) , visual analogue scale , nasal administration , pediatrics , population , prospective cohort study , physical therapy , immunology , nursing , environmental health
Background We previously reported a higher prevalence of nasal obstructive disorders (NOD) in pediatric patients with persistent allergic rhinitis (PER) not responding to medical treatment. The aim of this study was to determine the impact of NOD on quality of life (QoL) in this population. Methods Real‐life prospective study including 142 patients (41 children, 6‐11 years old and 101 adolescents, 12‐17 years old) with moderate and severe PER. After 2 months of medical treatment (intranasal steroids and antihistamines), patients were asked whether their symptoms had improved (yes/no) and classified accordingly in R, responders and NR, non‐responders. Nasal symptoms (visual analog scale, VAS), NOD (nasal endoscopy), and QoL (PRQLQ, AdolQRLQ) were also assessed. Results Sixty‐nine adolescents and 24 children were included in the NR group. NR presented worse QoL overall scores in adolescents (3.16±1.1 vs 1.63±0.99; P =.00001) and children (2.19±0.82 vs 1.51±0.77, P =.02). Medical treatment failure was associated with worse outcomes in QoL (adolescents OR: 1.6, P <.0001; children OR: 1.04, P =.036). Female adolescents presented worse QoL scores than males (3.19 vs 2.36, P =.001). The presence of obstructive septal deviation (OR: 1.02, P =.005), obstructive turbinate hyperplasia (OR: 1.03, P =.0006), and coexistence of both (OR=2.06, P =.001) was associated with worse QoL in adolescents. A strong and highly significant correlation was found between nasal symptoms VAS and QoL. Conclusion The presence of NOD, particularly in adolescents, is associated with poor QoL outcomes. Assessment of NOD in pediatric PER should be considered an essential approach to determine the response to treatment and its impact on patient's QoL.