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Eosinophilic esophagitis phenotypes: Ready for prime time?
Author(s) -
Atkins Dan,
Furuta Glenn T.,
Liacouras Chris A.,
Spergel Jonathan M.
Publication year - 2017
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12715
Subject(s) - eosinophilic esophagitis , medicine , dysphagia , phenotype , clinical phenotype , esophagitis , disease , dermatology , gastroenterology , surgery , reflux , biochemistry , chemistry , gene
Eosinophilic esophagitis (EoE) is one of the most common causes of reflux‐like symptoms and feeding problems in children and food impaction and dysphagia in adults with a prevalence of 1:2500. Therapeutic options include diet, use of swallowed corticosteroids, or dilation. In the last several years, recent clinical and translational researches have identified some common and distinctive features, for example, the varying response to diet and medications. As EoE shares some characteristics with both asthma and inflammatory bowel disease, the advances in these fields suggest that various phenotypes may also exist in patients with EoE. Here, we provide a rationale for EoE phenotypes and provide some suggestions for potential phenotypes based on histology, molecular signature, response to therapy or dietary therapy.