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Phenotypical characterization of peanut allergic children with differences in cross‐allergy to tree nuts and other legumes
Author(s) -
Cousin Mathias,
Verdun Stéphane,
Seynave Maxime,
Vilain AnneChristine,
Lansiaux Amélie,
Decoster Anne,
Sauvage Christine
Publication year - 2017
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12698
Subject(s) - peanut allergy , medicine , allergy , cohort , atopic dermatitis , cross sectional study , cohort study , cluster (spacecraft) , asthma , pediatrics , immunology , food allergy , pathology , computer science , programming language
Background Peanut allergy in children is often associated with allergies to tree nuts and/or legumes. The aim of this study was to analyze in cluster a cohort of children allergic to peanuts and assessed for cross‐reactivity to nuts and legumes and to identify different phenotypes. Methods We included retrospectively 317 children with peanut allergy evaluated at the Allergy Unit of the Saint Vincent Hospital of Lille in the last 12 years. A complete workup for peanut allergy and nuts and legumes was carried out for each patient. A hierarchical agglomerative clustering method was used to search for clusters of individuals in the evaluated cohort. Results Cross‐allergy to TN and/or other legumes was identified in 137 patients (43.2%), atopic dermatitis being a major risk factor (adjusted OR = 16 [95% CI : 7.4–37]; p < 0.001). Three phenotypes emerged from cluster analysis. Cluster 1 (72 patients) is characterized by high level of rA ra h 2, low threshold reactive doses for peanut and high proportion of asthma; Cluster 2 (93 patients) is characterized by high threshold reactive doses for peanut and the lowest proportion of cross‐allergy to TN and/or legumes; Cluster 3 (152 patients) has a high risk of cross‐allergy to TN and/or legumes and most patients suffer from eczema. Conclusions The three phenotypes highlighted by this study could be useful to identify children with high risk of cross‐allergic reaction to TN s and legumes early after PA diagnosis.