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Non‐IgE‐mediated gastrointestinal food allergies in children
Author(s) -
Caubet JeanChristoph,
Szajewska Hania,
Shamir Raanan,
NowakWęgrzyn Anna
Publication year - 2017
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12659
Subject(s) - medicine , food allergy , enterocolitis , irritable bowel syndrome , allergy , immunoglobulin e , immunology , enteropathy , oral food challenge , elimination diet , disease , gastroenterology , antibody
Non‐IgE‐mediated gastrointestinal food allergic disorders (non‐IgE‐ GI ‐ FA ) including food protein‐induced enterocolitis syndrome ( FPIES ), food protein‐induced enteropathy ( FPE ), and food protein‐induced allergic proctocolitis ( FPIAP ) are relatively uncommon in infants and young children, but are likely under‐diagnosed. Non‐IgE‐ GI ‐ FA have a favorable prognosis, with majority resolving by age 3–5 years. Diagnosis relies on the recognition of symptoms pattern in FPIAP and FPIES and biopsy in FPE . Further studies are needed for a better understanding of the pathomechanism, which will lead eventually to the development of diagnostic tests and treatments. Limited evidence supports the role of food allergens in subsets of constipation, gastroesophageal reflux disease, irritable bowel syndrome, and colic. The immunologic pathomechanism is not fully understood and empiric prolonged avoidance of food allergens should be limited to minimize nutrient deficiency and feeding disorders/food aversions in infants.