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Associations of maternal and fetal 25‐hydroxyvitamin D levels with childhood eczema: The Generation R Study
Author(s) -
Gazibara Tatjana,
Elbert Niels J.,
Dekker Herman T.,
Jongste Johan C.,
Reiss Irwin,
McGrath John J.,
Eyles Darryl W.,
Burne Thomas H.,
Tiemeier Henning,
Jaddoe Vincent W. V.,
Pasmans Suzanne G. M. A.,
Duijts Liesbeth
Publication year - 2016
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12530
Subject(s) - medicine , vitamin d and neurology , gestation , odds ratio , population , vitamin d deficiency , cord blood , gestational age , pregnancy , prospective cohort study , confidence interval , pediatrics , obstetrics , genetics , environmental health , biology
Background Exposure to low levels of vitamin D in fetal life might affect the developing immune system, and subsequently the risk of childhood eczema. We examined whether 25‐hydroxyvitamin D levels in mid‐gestation and at birth were associated with the risk of eczema until the age of 4 years. Methods In a population‐based prospective cohort study of 3019 mothers and their children, maternal blood samples in mid‐gestation and umbilical cord blood samples at birth were used to determine 25‐hydroxyvitamin D levels (severely deficient <25.0 nmol/l, deficient 25.0–49.9 nmol/l, sufficient 50.0–74.9 nmol/l, optimal ≥75.0 nmol/l). Eczema was prospectively assessed by annual questionnaires until the age of 4 years. Eczema patterns included never, early (age ≤1 year only), late (age >1 year only), and persistent eczema (age ≤ and >1 year). Data were assessed using the generalized estimating equations and multinomial regression models. Results Compared with the optimal 25‐hydroxyvitamin D group, sufficient, deficient, and severely deficient groups of 25‐hydroxyvitamin D level in mid‐gestation were not associated with the risk of overall eczema (odds ratios [95% confidence interval]: 1.09 [0.82, 1.43], 1.04 [0.87, 1.25], and 0.94 [0.81, 1.10], p‐values for trend >0.05), nor with eczema per year or eczema patterns in children up to the age of 4 years. Similarly, we observed no associations of 25‐hydroxyvitamin D groups at birth with any eczema outcome. Conclusion Our results suggest that levels of 25‐hydroxyvitamin D in mid‐gestation and at birth are not associated with the risk of overall eczema, eczema per year, or eczema patterns among children until the age of 4 years.