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Effect of indoor air quality of day care centers in children with different predisposition for asthma
Author(s) -
CarreiroMartins Pedro,
Papoila Ana Luisa,
Caires Iolanda,
Azevedo Susana,
Cano Maria Manuela,
Virella Daniel,
LeiriaPinto Paula,
Teixeira João Paulo,
RosadoPinto José,
AnnesiMaesano Isabella,
Neuparth Nuno
Publication year - 2016
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12521
Subject(s) - medicine , asthma , odds ratio , percentile , pediatrics , genetic predisposition , odds , indoor air quality , logistic regression , mathematics , disease , ecology , biology , statistics
Background Scarce information is available about the relationships between indoor air quality ( IAQ ) at day care centers ( DCC ), the estimated predisposition for asthma, and the actual wheezing susceptibility. Methods In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questionnaire and later by a follow‐up questionnaire about recent wheezing. A positive asthma predictive index ( API ) was considered as predisposition for asthma. Every DCC was audited for IAQ and monitored for chemical and biologic contaminants. Results We included 1191 children, with a median age of 43 (P 25 –P 75 : 25–58) months. Considering the overall sample, in the first questionnaire, associations were found between CO 2 concentration (increments of 200 ppm) and diagnosis of asthma ( OR : 1.10; 95% CI : 1.00–1.20). Each increment of 100 μg/m 3 of total volatile organic compounds ( TVOC ) and 1 μg of Der p1/g of dust were associated with wheezing in the previous 12 months ( OR : 1.06; 95% CI : 1.01–1.11 and OR : 1.06; 95% CI : 0.99–1.12, respectively). In the follow‐up questionnaire, TVOC were again associated with wheezing ( OR : 1.05; 95% CI : 1.00–1.11). Children exposed to fungal concentration above the 75th percentile had also higher odds of wheezing at follow‐up. TVOC were associated with wheezing in children with either negative or positive API . Conclusions IAQ in DCC seems to be associated with wheezing, in children with and without predisposition for asthma.