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Filaggrin genotype and skin diseases independent of atopic dermatitis in childhood
Author(s) -
Bager Peter,
Wohlfahrt Jan,
Thyssen Jacob Pontoppidan,
Melbye Mads
Publication year - 2016
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12511
Subject(s) - atopic dermatitis , medicine , filaggrin , rash , dermatology , atopy , dry skin , population , hazard ratio , odds ratio , allergy , immunology , confidence interval , environmental health
Background Filaggrin gene ( FLG ) mutations compromise skin barrier functions and increase risk of atopic dermatitis. We aimed to study effects on other skin diseases using unique data from the Danish registers. Methods FLG genotyping of a population‐based sample of 1547 children with extracted DNA and information on skin diseases from the Danish National Birth Cohort and Health Register, with 18 years follow‐up during years 1996–2013. Odds ratios (OR) and hazard ratios (HR) were estimated using logistic regression and Cox regression, respectively, and adjusted for physician‐diagnosed atopic dermatitis. Results FLG mutations were associated with increased risk of dry skin (OR 1.9, CI 1.1–3.1), and a decreased risk of fungal skin infections at age <18 months (OR 0.2, CI 0.1–0.8). There was no association with wart treatments (HR 1.0, CI 0.6–1.7). FLG mutations were associated with an increased risk of atopic dermatitis (OR 3.3, CI 2.1–5.3), dermatology consultations for allergy or rash (HR 2.2, CI 1.4–3.5), basic dermatology consultations at age <5 years (HR 2.2, CI 1.7–2.9), urticaria at age <18 months (OR 2.9, CI 1.0–7.9), and other rash at age <18 months (OR 2.1, CI 1.2–3.8). Conclusions FLG mutations may predispose to skin disease in young children including urticaria, and rash not recognized as atopic dermatitis although equally frequent. In clinical practice, FLG genotyping may help indicate the use of moisturizers to reduce skin problems.