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Pandemic influenza virus, pH 1N1, induces asthmatic symptoms via activation of innate lymphoid cells
Author(s) -
Shim D. H.,
Park Y. A.,
Kim M. J.,
Hong J. Y.,
Baek J. Y.,
Kim K. W.,
Byun Y.h.,
Seong B.L.,
Ryu S.,
Song M. K.,
Hong K.J.,
Na W.,
Song D.,
Park J. H.,
Sohn M. H.,
Lee J. M.
Publication year - 2015
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12462
Subject(s) - medicine , innate lymphoid cell , innate immune system , pandemic , virus , immunology , influenza a virus , virology , influenza pandemic , covid-19 , immune system , disease , infectious disease (medical specialty)
Abstract Background The pandemic strain of the influenza A virus ( pH 1N1) in 2009 caused many complications in patients. In this study, we introduce asthmatic symptoms as a complication of pH 1N1 infection in children, not having a relationship with asthma history. The aim of this study was to quantify asthmatic symptoms in pH 1N1‐infected children and elucidate the underlying mechanisms of airway hyper‐responsiveness ( AHR ) induced in a murine model of pH 1N1 infection. Methods As a retrospective study, pH 1N1‐infected children who were hospitalized with moderate to severe acute asthmatic symptoms were enrolled and administered a methacholine challenge test ( MCT ) at 3 months post‐discharge. Additionally, the induction of AHR by pH 1N1 infection was measured by MCT in wild‐type and Rag1 −/− mice. The effect of the innate immune response on the development of AHR following pH 1N1 infection was investigated. Results More than 70% of the pH 1N1‐infected children without a pre‐infection diagnosis of asthma had a negative response on the MCT . None of these children had recurrent wheezing or asthma during the 3 years following pH 1N1 infection. The development of AHR in pH 1N1‐infected mice was associated with an elevation in IL ‐33 and innate lymphoid cells 2 (ILC2). Conclusions This study demonstrates that pH 1N1 infection directly induces transient asthmatic symptoms in patients regardless of their medical history. pH 1N1 infection was shown to stimulate the rapid development of AHR and Th2‐type cytokine secretion in mice via the activation of ILC 2; it may be activated independently of adaptive immunity.