Premium
Indoor total volatile organic compounds exposure at 6 months followed by atopic dermatitis at 3 years in children
Author(s) -
Kwon Jung Hyun,
Kim Eunjeong,
Chang MoonHee,
Park Eun Ae,
Hong YunChul,
Ha Mina,
Park Hyesook,
Kim Yangho,
Park Choonghee,
Ha EunHee
Publication year - 2015
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12393
Subject(s) - atopic dermatitis , medicine , asthma , quartile , atopy , allergy , cohort , percentile , environmental health , confidence interval , dermatology , immunology , statistics , mathematics
Background Exposure to indoor air pollutants is thought to cause allergic inflammation. Volatile organic compounds ( VOC s) are one of the aggravating factors of asthma and other allergic diseases. However, the influence of VOC s on development of atopic dermatitis is ambiguous in the clinical field. We therefore investigated the associations of indoor total volatile organic compounds ( TVOC s) and development of atopic dermatitis in young Korean children. Methods From the birth cohort of a MO thers and Children's Environmental Health ( MOCEH ) study, 257 infants, whose parents agreed with the environmental measurement, were enrolled. Total VOC s were measured in infant's bedrooms at the age of 6 month. A total of 105 parents answered a questionnaire at 36 month. Concentrations of TVOC s were divided into two groups by third quartile (75th). Associations between the high VOC s exposure group and development of atopic dermatitis at the age of 36 months were estimated by multivariate logistic regression. Results The average concentration of TVOC s was 174.7 ± 115.1 ㎍/m 3 . We defined the high TVOC s exposure group by those with more than 75 percentile of the distribution (242.1 ㎍/m 3 ). An increased risk of atopic dermatitis was observed in the high TVOC s exposure group, after adjustment for parents history of allergy, household income, breast‐feeding longer than 6 month ( OR = 3.116, 95% Cl 1.041–9.323). Risk of atopic dermatitis was increased when the family bought new furniture within 1 yr. Conclusion Our results showed that exposure to high concentration of VOC s during infancy, an indoor pollutant, increased the risk of atopic dermatitis at 36 months.