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Ara h 2 and Ara h 6 sensitization predicts peanut allergy in Mediterranean pediatric patients
Author(s) -
Agabriel Chantal,
Ghazouani Ouafeh,
Birnbaum Joëlle,
Liabeuf Valérie,
Porri Françoise,
Gouitaa Marion,
Cleach Isabelle,
Grob JeanJacques,
Bongrand Pierre,
Sarles Jacques,
Vitte Joana
Publication year - 2014
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12299
Subject(s) - medicine , peanut allergy , sensitization , allergy , dermatology , immunology , food allergy
Abstract Background Peanut allergy ( PA ) management was improved by the introduction of molecular allergology, but guidelines for Mediterranean patients are lacking. We aimed at evaluating peanut component‐resolved diagnosis as a diagnostic and prognostic tool in children from Southern France. Methods In 181 pediatric patients, PA diagnosis was founded on medical history, skin prick testing, serum‐specific IgE to A rachis hypogea extract and components, Pru p 4, and plant carbohydrates, and oral food challenge. Allergen microarray was also performed in 68 of these patients. Results In peanut‐allergic children (n = 117), IgE to Ara h 6 were most prevalent (64%), followed by Ara h 2 (63%), Ara h 1 (60%), and Ara h 9 (52%). Ara h 6 was the best predictor of PA. The second best predictor was the ratio of Ara h 2 IgE to peanut IgE (cutoff 0.113). Persistent childhood PA was associated with complex molecular profiles. Comparison of singleplex and microarray results showed poor concordance for Ara h 2 and Ara h 9. Conclusion Ara h 6 and Ara h 2 are the best predictors of PA at diagnosis in Mediterranean pediatric patients. Ara h 1, Ara h 8, and molecular complexity are associated with PA persistence.