Neonatal hyperbilirubinemia and childhood allergic diseases: a systematic review

Studies have found a link between neonatal hyperbilirubinemia ( NNH ) and/or neonatal phototherapy ( NPT ) and childhood allergic diseases. The present systematic review was conducted to provide updated evidence and to provide direction regarding future research. A systematic search of the published literature was carried out. Observational studies including children up to 12 yr of age were included. Data extraction was carried out using a standardized data extraction form that was designed and pilot tested a priori . The analysis was carried out with the statistical software RevMan (version 5.2) [Protocol is registered at PROSPERO : CRD 42014009943]. Of 79 citations retrieved, a total of 7 good quality studies (n = 101,499) were included in the final analysis. There was a significant increase in the odds of asthma and allergic rhinitis ( AR ) after NNH [asthma, OR 4.26 (95% CI 4.04–4.5); AR , OR 5.37 (95% CI 4.16–6.92)] and after NPT [asthma, OR 3.81 (95% CI 3.53–4.11); AR , OR 3.04(95% CI 2.13–4.32)]. A similar increase in the trend was noted for late onset of asthma after NNH [ OR 4.1 (95% CI 2.82–5.94)], and hospitalization due to asthma after NPT [ OR 3.56 (95% CI 2.93–4.33)]. The GRADE evidence generated was of ‘low quality’. The current evidence finds a significant increase in the odds of childhood allergic diseases after NNH and/or NPT . As observational studies were included, the evidence generated was of ‘low quality’. Future studies should try to elucidate the pathophysiologic link between NNH and/or NPT and childhood allergic diseases.