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Role of specific I g E in predicting the clinical course of lentil allergy in children
Author(s) -
Yavuz Suleyman T.,
Sahiner Umit M.,
Buyuktiryaki Betul,
Tuncer Ayfer,
Yilmaz Ebru A.,
Cavkaytar Ozlem,
Karabulut Erdem,
Sackesen Cansin
Publication year - 2013
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12080
Subject(s) - medicine , allergy , food allergy , quartile , ingestion , anaphylaxis , pediatrics , disease , anaphylactic reactions , immunology , confidence interval
Background Legumes, and particularly lentils, are frequently consumed in M editerranean, M iddle E astern, and some A sian countries. The aim of this study was to document the demographic features of children with lentil allergy and to determine the role of specific I g E (s I g E ) in predicting the risk of clinical reactivity and disease persistence. Methods Thirty children were enrolled. The diagnosis of lentil allergy was based on convincing history of symptoms or anaphylaxis after the ingestion of lentils, with positive skin tests and/or s I g E to lentils. To determine the diagnosis and prognosis of lentil allergy, 24 children were evaluated with food challenges. Results The median age at the onset of symptoms was 1.5 yr (0.9–2.3) (inter‐quartile range). The most frequent symptoms were immediate cutaneous (97%) and respiratory (30%) reactions, whereas eight patients (27%) reported anaphylactic reactions. The median level of lentil s I g E at the time of diagnosis was 3 kU/l (1.2–9.6). Of the 24 challenges, 12 were positive. Fifteen patients (50%) outgrew the lentil allergy by the age of 3.5 (2.5–11) years. Children with an initial lentil s I g E < 4.9 kU/l had a significantly higher likelihood (68.4% vs. 18.2%) of outgrowing the lentil allergy than children with an initial lentil s I g E ≥ 4.9 k/l (p = 0.008). Conclusions Our results suggest that s I g E levels may be important for predicting clinical reactivity and persistence of lentil allergy.