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A randomized trial of L actobacillus plantarum CJLP 133 for the treatment of atopic dermatitis
Author(s) -
Han Youngshin,
Kim Bongjoon,
Ban Jeongsook,
Lee Jeongok,
Kim Beom Joon,
Choi Byung Sun,
Hwang Sehee,
Ahn Kangmo,
Kim Jihyun
Publication year - 2012
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/pai.12010
Subject(s) - scorad , medicine , atopic dermatitis , placebo , probiotic , lactobacillus plantarum , eosinophil , randomized controlled trial , gastroenterology , placebo controlled study , immunology , asthma , double blind , dermatology life quality index , lactic acid , alternative medicine , disease , pathology , biology , bacteria , genetics
Background There have been considerable disagreements regarding the therapeutic effects of probiotics in atopic dermatitis ( AD ). We performed this study to examine whether the oral administration of L actobacillus plantarum CJLP 133 improves pediatric AD . Methods In a randomized, double‐blind, placebo‐controlled study, either L . plantarum CJLP 133 at a dosage of 0.5 × 10 10 colony‐forming units or placebo in children aged 12 months to 13 yr was given twice a day for 12 wk. SCOring of Atopic Dermatitis ( SCORAD ) scores, eosinophil counts, serum total IgE, and cytokines were evaluated. Results Forty‐four of 58 patients in the probiotic group and 39 of 60 patients in the placebo group completed the study. The SCORAD score at week 14 was lower in the probiotic group than in the placebo group (p = 0.044). The mean change in the SCORAD score from weeks 2 to 14 was 9.1 in the probiotic group, which was greater than the mean change of 1.8 in the placebo group (p = 0.004). No statistical differences in the total use of topical corticosteroids were found between two groups (p = 0.815). In the probiotic group, the total eosinophil count was significantly lower at the end of the intervention compared to the baseline measurements (p = 0.023). Logarithmic IFN ‐γ and IL ‐4 were significantly decreased by the end of the intervention compared to baseline measurements in the probiotic group (p < 0.001 and 0.049). Conclusions Our results suggest that supplementation with probiotic L . plantarum CJLP 133 is beneficial in the treatment of pediatric AD .