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Isolated left bundle branch block in the young: case reports and review of literature
Author(s) -
Kohli Utkarsh,
Sriram Chenni S.,
Nayak Hemal M.
Publication year - 2021
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.14243
Subject(s) - medicine , left bundle branch block , natural history , pediatrics , coding (social sciences) , cardiology , heart failure , statistics , mathematics
Isolated left bundle branch block (LBBB) aberrancy is exceedingly rare in the young and its clinical and genetic determinants remain poorly characterized. Furthermore, there is conflicting data on its natural history in the pediatric age group patients. We report the rare phenotype of isolated typical LBBB aberrancy in two healthy children, one of whom carried a likely pathogenic mutation in the coding exon 1 of NKX2‐5 (p.Q22R, c.65A > G, rs201442000). Our findings suggest that isolated LBBB aberrancy could be non‐progressive in some children, at least in the short term. However, given the paucity of data on this entity, we recommend continued long‐term surveillance.