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Premature ventricular contraction detection for long‐term monitoring in an implantable cardiac monitor
Author(s) -
Lustgarten Daniel L.,
Rajagopal Gautham,
Reiland Jerry,
Koehler Jodi,
Sarkar Shantanu
Publication year - 2020
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.13903
Subject(s) - medicine , cardiology , cohort , algorithm , cardiomyopathy , confidence interval , heart failure , computer science
Background Premature ventricular complexes (PVCs) are an important therapeutic target in symptomatic patients and in the setting of PVC‐induced cardiomyopathy; however, measuring burden and therapeutic response is challenging. We developed and validated an algorithm for continuous long‐term monitoring of PVC burden in an insertable cardiac monitor (ICM). Methods A high‐specificity PVC detection algorithm was developed using real‐world ICM data and validated using simultaneous Holter data and real‐world ICM data. The PVC algorithm uses long‐short‐long RR interval sequence and morphology characteristics for three consecutive beats to detect the occurrence of single PVC beats. Data are expressed as gross incidence, patient average, and generalized estimating equation estimates, which were used to determine sensitivity, specificity, positive and negative predictive value (PPV, NPV). Results The PVC detection algorithm was developed on eighty‐seven 2‐min EGM strips recorded by an ICM to obtain a sensitivity and specificity of 75.9% and 98.8%. The ICM validation data cohort consisted of 787 ICM recorded ECG strips 7‐16 min in duration from 134 patients, in which the algorithm detected PVC beats with a sensitivity, specificity, PPV, and NPV of 75.2%, 99.6%, 75.9%, and 99.5%, respectively. In the Holter validation dataset with continuous 2‐h snippets from 20 patients, the algorithm sensitivity, specificity, PPV, and NPV were 74.4%, 99.6%, 68.8%, and 99.7%, respectively, for detecting PVC beats. Conclusions The PVC detection algorithm was able to achieve a high specificity with only 0.4% of the normal events being incorrectly identified as PVCs, while detecting around three of four PVCs on a continuous long‐term basis in ICMs.