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The effect of statins on the recurrence rate of atrial fibrillation after catheter ablation: A meta‐analysis
Author(s) -
Peng Hong,
Yang Yuan,
Zhao Yue,
Xiao Hua
Publication year - 2018
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.13485
Subject(s) - medicine , subgroup analysis , atrial fibrillation , meta analysis , randomized controlled trial , confidence interval , odds ratio , catheter ablation , cardiology , cochrane library , observational study
Background To more precisely evaluate the effect of statins on patients with atrial fibrillation (AF) after catheter ablation, we performed a meta‐analysis of published studies. Methods We searched PubMed, EMBASE, and Cochrane Library for all relevant published articles from the date of inception to April 2017. Odds ratios (OR) and 95% confidence intervals (CIs) were then calculated and pooled using a random‐effects model. Statistical heterogeneity was evaluated using the I 2 statistic. Results Nine studies with a total of 1,607 patients were included in the analysis. Overall, statins did not reduce the recurrence rate of AF after catheter ablation (OR 0.81, 95% CI 0.59–1.10, P = 0.18). However, in the subgroup analysis, the randomized control trial (RCT) group significantly reduced the recurrence of AF (OR 0.47, 95% CI 0.30–0.75, P = 0.001). Conversely, the retrospective cohort study subgroup also had a negative result (OR 1.03, 95% CI 0.78–1.36, P = 0.82). Conclusions Statin use was associated with a significantly lower AF recurrence rate in RCTs but not in the whole analysis and the observational studies.