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Ventricular arrhythmias involving the His‐Purkinje system in the structurally abnormal heart
Author(s) -
He Beixin Julie,
Boyden Penelope,
Scheinman Melvin
Publication year - 2018
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.13465
Subject(s) - medicine , cardiology , electrical conduction system of the heart , purkinje fibers , ventricular tachycardia , disease , heart disease , neuroscience , electrocardiography , electrophysiology , biology
His‐Purkinje‐related ventricular arrhythmias are a subset of ventricular tachycardias that use the specialized cardiac conduction system. These arrhythmias can occur in various different forms of structural heart disease. Here, we review the basic science discoveries and their analogous clinical observations that implicate the His‐Purkinje system as a crucial component of the arrhythmia circuit. While mutations serve the molecular basis for arrhythmias in the heritable cardiomyopathies, transcriptional and posttranslational changes constitute the adverse remodeling leading to arrhythmias in acquired structural heart disease. Additional studies on the electrical properties of the His‐Purkinje network and its interactions with the surrounding myocardium will improve the clinical diagnosis and treatment of these arrhythmias.