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J wave syndromes as a cause of malignant cardiac arrhythmias
Author(s) -
Di Diego José M.,
Antzelevitch Charles
Publication year - 2018
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.13408
Subject(s) - medicine , brugada syndrome , j wave , risk stratification , benign early repolarization , sudden cardiac death , cardiac arrhythmia , cardiology , broad spectrum , st segment , repolarization , long qt syndrome , intensive care medicine , qt interval , atrial fibrillation , myocardial infarction , electrophysiology , chemistry , combinatorial chemistry
The J wave syndromes, including the Brugada (BrS) and early repolarization (ERS) syndromes, are characterized by the manifestation of prominent J waves in the electrocardiogram appearing as an ST segment elevation and the development of life‐threatening cardiac arrhythmias. BrS and ERS differ with respect to the magnitude and lead location of abnormal J waves and are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. Despite over 25 years of intensive research, risk stratification and the approach to therapy of these two inherited cardiac arrhythmia syndromes are still rapidly evolving. Our objective in this review is to provide an integrated synopsis of the clinical characteristics, risk stratifiers, as well as the molecular, ionic, cellular, and genetic mechanisms underlying these two syndromes that have captured the interest and attention of the cardiology community over the past two decades.