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Acquired long QT syndrome and torsade de pointes
Author(s) -
ElSherif Nabil,
Turitto Gioia,
Boutjdir Mohamed
Publication year - 2018
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.13296
Subject(s) - medicine , long qt syndrome , channelopathy , cardiac electrophysiology , presentation (obstetrics) , sudden cardiac death , intensive care medicine , cardiology , qt interval , electrophysiology , surgery
Abstract Since its initial description by Jervell and Lange‐Nielsen in 1957, the congenital long QT syndrome (LQTS) has been the most investigated cardiac ion channelopathy. Although congenital LQTS continues to remain the domain of cardiologists, cardiac electrophysiologists, and specialized centers, the by far more frequent acquired drug‐induced LQTS is the domain of all physicians and other members of the health care team who are required to make therapeutic decisions. This report will review the electrophysiological mechanisms of LQTS and torsade de pointes, electrocardiographic characteristics of acquired LQTS, its clinical presentation, management, and future directions in the field.