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The Neutrophil‐to‐Lymphocyte Ratio Predicts All‐Cause Mortality in Patients with Implantable Cardioverter Defibrillators
Author(s) -
HASHIMOTO NAOAKI,
ARIMOTO TAKANORI,
NARUMI TARO,
IWAYAMA TADATERU,
KUTSUZAWA DAISUKE,
ISHIGAKI DAISUKE,
KUMAGAI YU,
TAMURA HARUTOSHI,
NISHIYAMA SATOSHI,
TAKAHASHI HIROKI,
SHISHIDO TETSURO,
MIYAMOTO TAKUYA,
WATANABE TETSU,
KUBOTA ISAO
Publication year - 2017
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.13003
Subject(s) - medicine , neutrophil to lymphocyte ratio , cardiology , implantable cardioverter defibrillator , intensive care medicine , lymphocyte
Background The relationship between the neutrophil‐to‐lymphocyte ratio (NLR) and outcome in patients with implantable cardioverter‐defibrillators (ICDs) is unclear. Methods and Results Consecutive patients with cardiomyopathy who had received an ICD (n = 120, mean age 64 ± 11 years) were prospectively enrolled. Blood samples were obtained on the morning of the day of implantation. Patients were followed for a median period of 61.2 months, to an endpoint of all‐cause mortality or appropriate ICD shock, which occurred in 35 (29%) and 28 (23%) patients, respectively. Multivariate Cox analysis revealed that secondary prevention was only associated with appropriate ICD shocks. The NLR, brain natriuretic peptide level, and estimated glomerular filtration rate were independent predictors of all‐cause mortality but not of appropriate ICD shocks. Subgroup analysis revealed that a high NLR (≥2.1) was valuable for anticipating all‐cause mortality among patients who had received ICDs for primary or secondary prevention. A high NLR was also associated with death prior to appropriate ICD shock. Conclusion Evaluating the NLR may be useful for predicting outcomes in patients with cardiomyopathy who have received ICDs.