Premium
CTA Detection of Left Atrial Stasis and Thrombus in Patients with Atrial Fibrillation
Author(s) -
WANG LIN,
KADIYALA MADHAVI,
KOSS ELANA,
YARRAMANENI ABHIMANYU,
RAPELJE KATHLEEN,
KAMPFER STEPHANIE,
REICHEK NATHANIEL,
HOCH DAVID,
JAYAM VINAY,
LEVINE JOSEPH,
CAO JIE J.
Publication year - 2016
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.12959
Subject(s) - medicine , thrombus , atrial fibrillation , cardiology , blood stasis , radiology , ablation , transesophageal echocardiogram , pathology , alternative medicine , traditional chinese medicine
Background We investigated computed tomography (CT) angiography (CTA) in assessment of left atrial appendage (LAA) stasis and thrombus in preprocedural evaluation for atrial fibrillation (AF) ablation in a large community cohort. Methods and Results We reviewed CTA and transesophageal echocardiographic images obtained in 861 consecutive patients with a history of AF undergoing same‐day CTA and transesophageal echocardiogram (TEE) before AF ablation at a single hospital (2006–2013). CTA findings of LAA filling defects from acquisitions without electrocardiogram gating were compared to TEE features of LAA stasis (grade 0–4) and thrombus. Stasis grade 0 or 1 by TEE in the absence of thrombus was defined as a negative result. In addition, LAA peak flow velocity was assessed by TEE. Average age was 61 ± 10 years and 75% were male. On CTA, 161 patients (19%) had LAA filling defects on CTA and 21 had ≥grade 2 stasis on TEE, including two with thrombus, resulting in a positive predictive value of only 13%. However, among 670 CTA‐negative patients, 669 (99%) were negative for thrombus or stasis by TEE with one false‐negative CTA in a patient with grade 2 stasis by TEE but no thrombus, yielding a negative predictive value of 99.9%. Slow LAA Doppler flow velocity was the most important determinant of false‐positive CTA results in multivariate analysis (P < 0.0001) Conclusion LAA filling defects on CT are associated with slow LAA flow velocity. AF patients without LAA filing defects on CT are free of significant stasis and thrombus on TEE. It may be possible to eliminate TEE in up to 80% of AF ablation patients based on negative CTA findings.