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A Preclinical Study of an Implanted Device in the Pulmonary Veins, Intended for the Treatment of Atrial Fibrillation in an Ovine Model
Author(s) -
VANDECASTEELE TIM,
BOUSSY TIM,
PHILPOTT MATTHEW,
CLEMENT ELI,
SCHAUVLIEGE STIJN,
VAN DEN BROECK WIM,
VAN LOON GUNTHER,
CORNILLIE PIETER,
VAN LANGENHOVE GLENN
Publication year - 2016
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.12899
Subject(s) - medicine , ablation , pulmonary vein , atrial fibrillation , implant , ablation of atrial fibrillation , cardiology , vein , surgery , radiology
Background Atrial fibrillation is the most frequent arrhythmia in adults of which the interventional cure is hampered by high recurrence rates. Recurrence after ablation is due to an incomplete isolation of the pulmonary veins. A new ablation technique was performed, in the antra of ovine pulmonary veins, by device implantation, which was heated through a wireless heat‐generating system. Methods and Results Implants were placed transatrially in the pulmonary veins of sheep. Using a wireless heating system, the energy was afterward transferred through wires to the implanted device according to a defined protocol. The position of the implant and the applied lesions were macroscopically evaluated. Samples of the ablated tissue of the atrio‐pulmonary vein junction were histologically and immunohistochemically examined. Conclusions Six ablation procedures in four sheep were successfully performed without adverse cardiac reactions. Implantation of the device and the wireless heat generation was feasible. Sufficient heat was produced at the level of the antra of the pulmonary veins to create ablation lesions, which were histologically and immunohistochemically confirmed.