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Gene Polymorphism of the Adenosine A2a Receptor in Patients with Vasovagal Syncope
Author(s) -
MITRO PETER,
HABALOVA VIERA,
EVIN LUKAS,
MULLER ERVIN,
SIMURDA MILOS,
SLABA EVA,
MURIN PAVOL,
VALOCIK GABRIEL
Publication year - 2016
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.12806
Subject(s) - medicine , vasovagal syncope , adenosine a2a receptor , adenosine , syncope (phonology) , genotype , polymorphism (computer science) , single nucleotide polymorphism , gastroenterology , adenosine receptor , gene polymorphism , cardiology , endocrinology , receptor , gene , genetics , biology , agonist
Background Adenosine may play a role in the pathogenesis of vasovagal syncope (VVS). The aim of the study was to evaluate the adenosine A 2A receptor gene 1083 T > C polymorphism in patients with syncope and its possible association with results of head‐up tilt test (HUT). Methods Three hundred and forty‐seven consecutive patients (mean age 47.3 ± 18.5 years, 132 men, 215 women) with one or more syncopal episodes underwent HUT as part of standardized diagnostic evaluation. HUT was positive in 207 patients (75 males, mean age 44.7 ± 18.6 years) and negative in 140 patients (58 males, mean age 48.17 ± 18.8 years). One thousand and eighty‐three T > C single nucleotide polymorphism in the adenosine A 2A receptor gene (rs5751876) was evaluated in 347 patients with syncope and in 85 subjects without history of syncope (54 men, mean age 41.7 ± 16.3). Results Adenosine A 2A receptor 1083 T > C polymorphism was not associated with the positivity of HUT. Blood pressure and heart rate response to tilting was similar in all genotypes. Low frequency (LF) power was significantly lower in CC genotype compared to CT genotype in early phase of tilt (log LF 2.69 ± 0.61 vs 3.20 ± 0.60; P = 0.01) and at the time of syncope (log LF 2.60 ± 0.63 vs 2.77 ± 0.48; P = 0.04). Conclusions Adenosine A 2A receptor 1083 T > C polymorphism is not associated with the positivity of HUT and its proposed role in predisposition to VVS was not confirmed. CC genotype may be associated with lower sympathetic activity during HUT.