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Two Cases of LQT Syndrome with Malignant Syncope after Switch from Propranolol to Bisoprolol
Author(s) -
KESEK MILOS,
RYDBERG ANNIKA,
JENSEN STEEN M.
Publication year - 2016
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.12783
Subject(s) - medicine , propranolol , bisoprolol , asymptomatic , cardiology , tachycardia , anesthesia , heart failure
Propranolol in slow‐release form has been the first‐line treatment in long QT (LQT) until it was withdrawn from the market. We describe two cases where a switch to bisoprolol resulted in worsening of arrhythmia control: A man with LQT2, asymptomatic on propranolol, experienced syncope after switching to bisoprolol 5 mg daily. He switched back to propranolol and has remained asymptomatic during subsequent 12 months. A man with classical Jervell Lange‐Nielsen syndrome, previous gangliectomy, and ICD implantation, switched to bisoprolol 5 mg daily. Four months later he experienced a tachycardia storm. He switched back to propranolol and has remained free from arrhythmias during subsequent 12 months.