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Differences of Mortality Rates between Pocket and Nonpocket Cardiovascular Implantable Electronic Device Infections
Author(s) -
LEE DONG HEUN,
GRACELY EDWARD J.,
ALEEM SARAH Y.,
KUTALEK STEVEN P.,
VIELEMEYER OLE
Publication year - 2015
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.12748
Subject(s) - medicine , bacteremia , hazard ratio , confidence interval , infective endocarditis , mortality rate , endocarditis , surgery , antibiotics , microbiology and biotechnology , biology
Background A steady rise in the use of cardiovascular implantable electronic devices (CIEDs), particularly in the elderly, has led to an increase in device‐related infections. Although often studied and reported as a single entity, these complications in fact comprise a heterogeneous group. Specific subgroups may be associated with distinct mortality risks . Methods Medical records of all patients who underwent device extraction for CIED‐related infection at a single tertiary referral center between 1991 and 2007 were reviewed. Infections were divided into four subgroups: primary pocket site infection (PPSI), pocket site infection with bacteremia, primary/isolated bacteremia (PIB), and device‐related infective endocarditis (DRIE). Clinical presentation, laboratory data, and mortality rates were obtained by chart review and by querying the Social Security Death Index . Results A total of 387 cases were analyzed. The overall in‐hospital and 1‐year all‐cause mortality rates were 7.2% and 25.3%, respectively. Patients with PIB or DRIE had significantly higher mortality rates (hazard ratio [HR] 2.3; 95% confidence interval [CI] 1.2–4.6 and HR 2.5; 95% CI 1.6–4.1, respectively) when compared with patients in the PPSI group. Patients who did not receive a new device during the initial admission also had a higher 1‐year mortality rate compared to those who did (HR 2.7; 95% CI 1.8–4.1) . Conclusions Our patients with CIED‐related infections requiring extraction/hospitalization had a significant mortality risk. Presence of pocket site infection carried a more favorable prognosis, regardless of the presence of bacteremia. Early detection and prevention of CIED‐related infections with PIB (i.e., no pocket site involvement), especially for high‐risk populations, is needed .