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The rs3807989 G/A Polymorphism in CAV1 is Associated with the Risk of Atrial Fibrillation in Chinese Han Populations
Author(s) -
LIU YAOWU,
NI BIXIAN,
LIN YUAN,
CHEN XINGUANG,
CHEN MINGLONG,
HU ZHIBIN,
ZHANG FENGXIANG
Publication year - 2015
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/pace.12494
Subject(s) - medicine , single nucleotide polymorphism , odds ratio , logistic regression , confidence interval , snp , atrial fibrillation , han chinese , polymorphism (computer science) , genetics , genotype , bioinformatics , gene , biology
Background A recent meta‐analysis of several genome‐wide association studies identified six new susceptibility single nucleotide polymorphisms (SNPs) for atrial fibrillation (AF) in individuals of the European ancestry. We aimed to replicate the associations between these SNPs and the risk of AF in a Chinese Han population. Methods We genotyped six SNPs (rs3903239 in PRRX1, rs3807989 in CAV1, rs10821415 in C9orf3, rs10824026 in SYNPO2L, rs1152591 in SYNE2, and rs7164883 in HCN4) using the middle‐throughput iPLEX Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models. Results We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 non‐AF controls. Among the six SNPs analyzed in the study, the SNP rs3807989 in CAV1 on chromosome 7q31 was found to be significantly associated with a decreased risk of AF (crude OR = 0.76, 95% CI: 0.64–0.89, P = 0.001; adjusted OR = 0.75, 95% CI: 0.63–0.89, P = 0.001). There were no significant associations between the other five loci and AF risk. Conclusion Our results confirmed that CAV1 rs3807989 may contribute to a decreased AF risk in Chinese Han populations. However, further validation studies with different ethnic backgrounds and biological function analyses are warranted to confirm our finding.