Open AccessBone Morphogenetic Protein‐2 and Vascular Endothelial Growth Factor in Bone Tissue Regeneration: New Insight and Perspectives
Author(s) -
Aryal Rajendra,
Chen Xiaopeng,
Fang Cheng,
Hu Yongcheng
Publication year - 2014
Publication title -
orthopaedic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 23
eISSN - 1757-7861
pISSN - 1757-7853
DOI - 10.1111/os.12112
Subject(s) - bone morphogenetic protein , regeneration (biology) , medicine , bone healing , regenerative medicine , bone morphogenetic protein 2 , tissue engineering , bone tissue , growth factor , pathology , stem cell , anatomy , microbiology and biotechnology , biomedical engineering , biology , biochemistry , receptor , gene , in vitro
The study of bone tissue regeneration in orthopaedic diseases has stimulated great interest among bone tissue engineering specialists and orthopaedic surgeons. Combinations of biomaterials, growth factors and stem cells for repairing bone have been much studied and researched, yet remain a challenge for both scientists and clinicians pursuing regenerative medicine. The purpose of this review was to elucidate the role of sequential release of bone morphogenetic protein‐2 and vascular endothelial growth factor in producing better outcomes in the field of bone tissue regeneration.