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The RagA and RagB proteins of Porphyromonas gingivalis
Author(s) -
Potempa Jan,
Madej Mariusz,
Scott David A.
Publication year - 2021
Publication title -
molecular oral microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 77
eISSN - 2041-1014
pISSN - 2041-1006
DOI - 10.1111/omi.12345
Subject(s) - porphyromonas gingivalis , virulence , biology , microbiology and biotechnology , pathogen , bacterial outer membrane , periodontal pathogen , function (biology) , bacteria , escherichia coli , biochemistry , gene , genetics
RagA and RagB proteins are major components of the outer membrane of the oral pathogen Porphyromonas gingivalis and, while recently suggested to represent a novel peptide uptake system, their full function is still under investigation. Herein, we (a) discuss the evidence that the rag locus contributes to P. gingivalis virulence; (b) provide insight to Rag protein potential biological function in macromolecular transport and other aspects of bacterial physiology; (c) address the host response to Rag proteins which are immunodominant and immunomodulatory; and (d) review the potential of Rag‐focused therapeutic strategies for the control of periodontal diseases.