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Prognostic value of pretreatment cardiovascular biomarkers in head and neck squamous cell carcinoma
Author(s) -
Oliveira Karine Gadioli,
Thebit Marcela Marçal,
Andrade Tadeu Uggere,
Campos Fabiana Vasconcelos,
Podestá Jose Roberto Vasconcelos,
Zeidler Sandra Lucia Ventorin Von,
Bissoli Nazaré Souza,
Gouvea Sonia Alves
Publication year - 2021
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13691
Subject(s) - medicine , hazard ratio , proportional hazards model , oncology , head and neck squamous cell carcinoma , troponin complex , gastroenterology , troponin , cardiology , head and neck cancer , radiation therapy , confidence interval , myocardial infarction
Abstract Objectives To examine the prognostic significance of pretreatment C‐reactive protein (CRP), N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), and cardiac troponin T (cTnT) levels on all‐cause mortality 3 years after head and neck squamous cell carcinoma (HNSCC) diagnosis. Subjects and Methods Data from 118 consecutive HNSCC patients, treated between 2012 and 2015, were evaluated prospectively. The impact of CRP, high‐sensitive (hs)‐cTnT, and NT‐proBNP levels on the 3‐year overall survival was estimated using the Kaplan–Meier method and Cox proportional hazard models. Results During the 36‐month follow‐up, 37 patients (31.35%) died. Multivariate analysis revealed that elevated CRP (Hazard ratio: 3.71, 95% CI: 1.44–9.53, p = .007) and NT‐proBNP levels (Hazard ratio: 5.04, 95% CI: 2.02–12.55, p = .001) were associated with negative prognosis, independent on age, sex, smoking and alcohol status, TNM classification, tumor site, body mass index (BMI), systolic blood pressure (SBP), and treatment modality (except for radiotherapy). hs‐cTnT had no influence over the prognosis, but it was correlated with TNM classification and SBP. CRP was significantly correlated with BMI and TNM classification, and NT‐proBNP with SBP and hs‐cTnT. Conclusions Pretreatment CRP and NT‐proBNP levels were identified as independent prognostic markers for poor clinical outcome 3 years after HNSCC diagnosis.