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Photobiomodulation is effective in oral lichen planus: A randomized, controlled, double‐blind study
Author(s) -
Ferri Elza P.,
Cunha Karen R. L.,
Abboud Clery S.,
Barros Gallo Camila,
Sousa Sobral Sérgio,
Fatima Teixeira da Silva Daniela,
Horliana Anna Carolina R. T.,
Franco Adriana L.d.S.,
Rodrigues Maria Fernanda Setúbal D.
Publication year - 2021
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13662
Subject(s) - medicine , clobetasol propionate , oral lichen planus , placebo , adverse effect , dermatology , clinical trial , pathology , psoriasis , alternative medicine
Objectives To compare the efficacy of photobiomodulation to that of topical clobetasol 0.05% in patients with symptomatic oral lichen planus (OLP). Subjects Thirty‐four patients with symptomatic OLP were randomly allocated into two groups: (a) the Control group ( n = 17), application of topical clobetasol propionate 0.05% three times a day for 30 consecutive days with laser placebo applied twice a week to mask the treatment, and (b) the photobiomodulation group ( n = 17), laser application twice a week, totalling 8 sessions, and gel placebo for 30 consecutive days to mask the treatment. Evaluations were performed once a week during treatment and 30, 60 and 90 days after treatment. The following parameters were evaluated: pain, clinical scores, clinical resolution and recurrence rate. Results Photobiomodulation and propionate clobetasol 0.05% were able to significantly decrease pain in oral lichen planus patients and improve clinical scores during treatment and follow‐up. Both the Control and photobiomodulation groups presented similar clinical resolution and recurrence rates. Most importantly, no difference was observed between treatments during treatment and follow‐up. Conclusions These findings indicate that photobiomodulation twice a week is as effective as corticoid therapy in treating oral lichen planus. Moreover, photobiomodulation is a safe and non‐invasive therapy with the remarkable advantage of no adverse effects.