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Vitamin D oral gel for prevention of radiation‐induced oral mucositis: A randomized clinical trial
Author(s) -
Bakr Islam S.,
Zaki Azza M.,
ElMoslemany Riham M.,
Elsaka Rasha O.
Publication year - 2021
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13650
Subject(s) - mucositis , medicine , radiation therapy , randomized controlled trial , gastroenterology , clinical trial , vitamin e , head and neck cancer , vitamin , surgery , chemistry , antioxidant , biochemistry
Objectives The aim of this clinical trial is to evaluate the effectiveness of topical oral vitamin D gel in prevention of radiation‐induced oral mucositis. Material and Methods A three‐armed randomized controlled clinical trial on forty‐five head and neck cancer patients was conducted. First group: conventional treatment. Second group: Topical oral vitamin D gel. Third group: topical oral vitamin D gel plus the conventional treatment. All the patients were examined clinically three and six weeks after the start of radiotherapy for pain and WHO mucositis score. Results After 6 weeks of radiotherapy, (33.5%) the patients in control group developed high‐grade severity of oral mucositis while the patients in the two‐test groups “vitamin D group and combined therapy group” remained with low‐grade severity or with complete remission. Mean pain scores showed a significant decrease in the combined therapy group and to a close degree in vitamin D group rather than the control group. Conclusion Topical oral vitamin D gel has a beneficial effect in lowering oral mucositis development and in reducing pain sensation during the radiation period especially when combined with conventional therapeutic agents.