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Clinicopathological and genetic characteristics of diffuse large B‐cell lymphoma of the oropharyngeal and maxillofacial region
Author(s) -
Xia Shu,
Yue Junqiu,
Chen Xinming,
Hu Yaying,
Guo Fang,
Zhang Jiali
Publication year - 2021
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13578
Subject(s) - bcl6 , fluorescence in situ hybridization , immunohistochemistry , lymphoma , diffuse large b cell lymphoma , chromosomal translocation , pathology , univariate analysis , cancer research , gene rearrangement , gene expression , medicine , biology , oncology , gene , multivariate analysis , b cell , antibody , immunology , genetics , germinal center , chromosome
Objectives The study was aimed to analyze the clinicopathological and molecular pathological features of diffuse large B‐cell lymphoma (DLBCL) in the oropharyngeal and maxillofacial region. Subjects and methods A retrospective review was performed with 36 patients who were diagnosed with primary DLBCL of the oropharyngeal and maxillofacial region from 2009 to 2017 in the Department of Pathology at the Hospital of Stomatology, Wuhan University. Immunohistochemistry and fluorescence in situ hybridization were performed. Results Gene rearrangements of BCL2, BCL6, and MYC were observed in 5.6%, 33.3%, and 22.2%, respectively, including two double‐hit and one triple‐hit DLBCL (8.3%). There was a significant correlation between MYC protein expression and gene translocation (rs = 0.679, p < .001). However, 25% of cases with MYC rearrangement showed low MYC protein expression. In univariate analysis, MYC protein expression, BCL2 rearrangement, MYC rearrangement, and double/triple‐hit DLBCL were associated with shorter overall survival, whereas only MYC protein expression was an independent prognostic value in multivariate model. Conclusions MYC protein expression was an essential prognostic marker of DLBCL in the oropharyngeal and maxillofacial region. Notably, immunohistochemical staining of MYC, BCL2, and BCL6 could not predict their gene rearrangements, although MYC protein expression was correlated with gene translocation.