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Periodontitis in tonsil cancer patients—A comparative study in accordance with tumour p16 status
Author(s) -
Keinänen Arvi,
MarinescuGava Magdalena,
Uittamo Johanna,
Hagström Jaana,
Marttila Emilia,
Snäll Johanna
Publication year - 2020
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13437
Subject(s) - medicine , dentistry , periodontitis , statistical significance , tonsil , gastroenterology , surgery
Objectives We assessed the periodontal situation radiologically according to tumour p16 status. Materials and methods Patients with a diagnosis of tonsillar cancer and availability of a digital panoramic radiograph (DPR) during a 5‐year period were included in this retrospective study. The predictor variables were periodontal stability, marginal bone loss, marginal bone loss without periodontal stability and total number of teeth. Periodontal status was compared with p16 status, age, gender, smoking and alcohol use. Results Among 115 patients included in the analyses (p16‐negative, n = 24; p16‐positive, n = 91), smoking ( p < .0001), heavy alcohol use ( p < .0001) and total number of teeth ( p = .0001) were significantly associated with p16 status. Current smoking (OR = 7.3) and heavy alcohol use (OR = 10.1) increased the risk of p16‐negative cancer. Conclusions Patients with p16‐negative tonsillar carcinoma had less teeth than patients with p16‐positive tumours. Other periodontal findings were common in both groups without statistical significance. Heavy alcohol use and smoking were the most important risk factors for p16‐negative tonsillar carcinoma.