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The role of peripheral opioid receptors in orofacial pain
Author(s) -
Liu Qing,
Fan Wenguo,
He Hongwen,
Huang Fang
Publication year - 2021
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13435
Subject(s) - orofacial pain , peripheral , opioid , trigeminal nerve , receptor , medicine , neuroscience , psychology , anesthesia , surgery
Opioid receptors are widely distributed in the central and peripheral nervous systems and non‐neuronal tissues. Numerous researchers have noted the pivotal role of peripheral opioid receptors (PORs) in analgesia. Accumulating evidence has shown the existence of PORs in the trigeminal nerve system, indicating that PORs may be involved in the modulation of orofacial pain. In this review, we summarise the recent evidence for the role of PORs in orofacial pain and discuss the possible cellular mechanisms.