Premium
Evaluating the measurement properties of patient‐reported outcome measures in radiotherapy‐induced xerostomia
Author(s) -
Assas Motaz,
Wiriyakijja Paswach,
Fedele Stefano,
Porter Stephen,
Ní Ríordáin Richeal
Publication year - 2021
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13416
Subject(s) - medicine , radiation therapy , patient reported outcome , outcome (game theory) , dentistry , radiology , quality of life (healthcare) , mathematics , nursing , mathematical economics
Objective Radiotherapy‐induced xerostomia (RIX) is one of the most common adverse effects of radiotherapy to the head and neck, and a major determinant of survivors’ quality of life. A number of patient‐reported outcome measures (PROMs) have been used in clinical trials of therapeutic interventions for RIX; however, little is known regarding their measurement properties and methodological quality. Methods We conducted a systematic literature search in Embase, MEDLINE and PsycINFO for articles published up to May 2019 and evaluating at least one measurement property of PROMs relevant to RIX. The COSMIN guidelines were used to assess relevant measurement properties and methodological quality. Results Nine validations studies were identified reporting on four PROMs relevant to RIX. The Xerostomia Questionnaire (XQ) showed overall high‐quality evidence for structural validity and internal consistency, but low‐quality evidence supporting reliability. The methodological quality of the Groningen Radiotherapy‐Induced Xerostomia scale (GRIX), Xerostomia Inventory (XI) and the Xerostomia Quality of Life Scale (XeQoLS) was relatively low for all measurement properties. Conclusions The XQ was found to have the highest potential to capture changes in RIX according to COSMIN guidelines. Additional validation studies are required to further understand the methodological quality of the XI, GRIX and XeQoLS.