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The diagnostic accuracy of the HIV 1/2/subtype O Tri‐line rapid test compared with ELISA: A pilot study
Author(s) -
Manenzhe Shumani Charlotte,
Ngwenya Sizakele Pride,
Shangase Sindisiwe Londiwe
Publication year - 2020
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13399
Subject(s) - medicine , gold standard (test) , human immunodeficiency virus (hiv) , retrospective cohort study , hiv screening , hiv test , diagnostic accuracy , second line , first line , immunology , population , men who have sex with men , environmental health , syphilis , health facility , health services
Background Accurate HIV diagnosis is essential for appropriate patient care. Rapid tests (RTs) are considered key to HIV screening and management. Some studies have found RTs to be comparable with the ELISA test whilst others have reported lower sensitivity. Aim and study design The aim of this retrospective, descriptive study was to evaluate the sensitivity and specificity of the HIV 1/2/O Tri‐line rapid test (HIV‐TRT) device compared with ELISA. Method The study sample comprised 45 records of patients who tested for HIV using the HIV‐TRT device and ELISA. Results As compared with ELISA as the 100% gold standard, the sensitivity of the HIV‐TRT was 80% (CI: 59%–93%) and specificity was 100% (CI: 83%–100%). ROC area of 0.9 at 95% CI was determined. Conclusion The low sensitivity of HIV‐TRT is a concern, since HIV screening in South Africa makes use of RTs.