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Association between hyperglycemia and the malignant transformation of oral leukoplakia in China
Author(s) -
Li Jin,
Liu Yang,
Zhang Hua,
Hua Hong
Publication year - 2020
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13372
Subject(s) - medicine , malignant transformation , tongue , epithelial dysplasia , lesion , dysplasia , univariate analysis , malignancy , oncology , physiology , pathology , gastroenterology , multivariate analysis
Objectives This study aimed to examine the association between hyperglycemia and the malignant transformation of oral leukoplakia (OLK). Patients and Methods This retrospective case–control study involved 133 patients with the malignant transformation of OLK into oral squamous cell carcinoma (case group) and 266 patients with untransformed OLK (control group). The clinical history and follow‐up data included age, gender, lesion size and location, and fasting plasma glucose. Logistic regression analysis, Kaplan–Meier survival analysis, and univariate and multivariate Cox regression analyses were used to assess the effects of risk factors on the malignant transformation of OLK. Results Hyperglycemia (adjusted hazard ratio [AHR] = 4.7, p = .001), non‐homogenous OLK (AHR = 3.0, p < .001), location of the lesion on the ventral surface of the tongue or floor of the mouth (AHR = 3.6, p < .001), and epithelial dysplasia (AHR = 2.8, p = .005) had significant effects on the malignant transformation of OLK. Conclusion Hyperglycemia, non‐homogenous OLK, location of the lesion on the ventral surface of the tongue or floor of the mouth, and epithelial dysplasia might be associated with malignant transformation of OLK.