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Histological characteristics of early‐stage oral tongue cancer in young versus older patients: A multicenter matched‐pair analysis
Author(s) -
Bello Ibrahim O.,
Almangush Alhadi,
Heikkinen Ilkka,
Haglund Caj,
Coletta Ricardo D.,
Kowalski Luiz P.,
Mäkitie Antti A.,
Nieminen Pentti,
Leivo Ilmo,
Salo Tuula
Publication year - 2020
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13288
Subject(s) - stage (stratigraphy) , tongue , medicine , etiology , cancer , young adult , stroma , pathology , gastroenterology , oncology , biology , immunohistochemistry , paleontology
Little is known about the histopathological characteristics that may differentiate early oral tongue cancer (OTSCC) between young and older patients. From a total of 311 cases diagnosed with clinically early‐stage OTSCC at 6 institutions, only 42 patients were young patients were aged ≤45 years. For comparison, 42 patients >60 years old were matched for center of management, clinical stage and gender. We compared epithelial and stromal histopathologic parameters between the two groups. Most of the parameters were similar between the two groups, although the young patients appeared to have marginally higher intensity of tumor budding, histologic risk score, infiltrative pattern of invasion and tumor‐stroma ratio. However, none of the factors showed significant difference when comparing the two groups. The histological parameters reflect mechanisms of invasive growth and tissue response to invasive growth, but not the etiological difference in OTSCC between young and older patients. Further investigations are necessary to compare the genetic background of early OTSCC in the two groups.