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Up‐regulation of plasma lncRNA CACS15 distinguished early‐stage oral squamous cell carcinoma patient
Author(s) -
Zhang Xinyu,
Guo Bing,
Zhu Yun,
Xu Wanlin,
Ning Shangbo,
Liu Liu
Publication year - 2020
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13245
Subject(s) - meg3 , biomarker , basal cell , cell , cell growth , stage (stratigraphy) , carcinoma , cancer research , medicine , oncology , pathology , biology , downregulation and upregulation , long non coding rna , gene , biochemistry , paleontology
Objective To study the role of LncRNA CASC15 in oral squamous cell carcinoma. Results In the present study, we showed that plasma CASC15 was up‐regulated in stage I and II oral squamous cell carcinoma patients than in oral ulcer patients and healthy controls, while no significant correlation was found between oral ulcer patients and healthy controls. Up‐regulation of plasma CASC15 distinguished oral squamous cell carcinoma patients from oral ulcer patients and healthy controls. LncRNA MEG3 was inversely correlated with CASC15 in oral squamous cell carcinoma tissues. In oral squamous cell carcinoma cells, CASC15 over‐expression led to the inhibited expression of MEG3, and MEG3 over‐expression did not alter CASC15 expression. MEG3 over‐expression decreased, while CASC15 over‐expression increased the proliferation rate of oral squamous cell carcinoma cells. In addition, MEG3 over‐expression attenuated the effects of CASC15 over‐expression. Conclusion Therefore, CASC15 over‐expression may serve as a potential diagnostic biomarker for oral squamous cell carcinoma, and CASC15 may promote oral squamous cell carcinoma cell proliferation by down‐regulating MEG3.