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Association between severe periodontitis and chronic kidney disease severity in predialytic patients: A cross‐sectional study
Author(s) -
Schütz Jasper da Silva,
Azambuja Carolina Barrera,
Cunha Giuliano Reolon,
Cavagni Juliano,
Rösing Cassiano Kuchenbecker,
Haas Alex Nogueira,
Thomé Fernando Saldanha,
Fiorini Tiago
Publication year - 2020
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13236
Subject(s) - medicine , kidney disease , periodontitis , renal function , cross sectional study , nephrology , chronic periodontitis , epidemiology , population , periodontal examination , gastroenterology , pathology , environmental health
Objective The aim of this cross‐sectional study was to evaluate the association between periodontitis and different severities of chronic kidney disease (CKD) in predialytic patients. Materials and Methods Demographic, socioeconomic, and medical data of 139 patients from the nephrology service of one university hospital in Porto Alegre, Brazil, were obtained through interview and clinical records. Full‐mouth six‐sites per tooth periodontal examinations were performed. Associations between periodontitis, stages of CKD, and estimated glomerular filtration rate (eGFR) were estimated by multivariable models adjusted for sex, smoking, vitamin D supplementation, physical activity, and renal treatment duration. CKD was classified based on eGFR (<60 ml/min/1.73 m 2 ) estimated by the Chronic Kidney Disease Epidemiology Collaboration equation. Results Patients with severe periodontitis, compared to those without severe periodontitis, had 2.8 (95% CI: 1.25–6.62) and 3.4 (95% CI: 1.27–9.09) times higher risk of being in stages 4 and 5 of CKD, respectively. Having ≥ 2 teeth with clinical attachment loss (CAL) ≥6 mm increased 3.9 times the risk of being in stage 5 of CKD. Patients with severe periodontitis and ≥2 teeth with CAL ≥ 6 mm had 4.4 ml/min/1.73 2 and 5.2 ml/min/1.73 2 lower eGFR ( p ‐values < .05), respectively. Conclusion Severe periodontitis was associated with poor renal conditions in predialytic CKD patients, strengthening the importance of periodontal evaluation in such patient population.