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CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity
Author(s) -
Sakurai Kotaro,
Tomihara Kei,
Yamazaki Manabu,
Heshiki Wataru,
Moniruzzaman Rohan,
Sekido Katsuhisa,
Tachinami Hidetake,
Ikeda Atsushi,
Imaue Shuichi,
Fujiwara Kumiko,
Noguchi Makoto
Publication year - 2020
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13210
Subject(s) - cd36 , basal cell , cell growth , cancer research , medicine , biology , pathology , receptor , genetics
Objective Recent studies have demonstrated the pro‐tumour role of CD36 in multiple cancer types. However, its role has not been well elucidated in oral squamous cell carcinoma (OSCC). Here, we aimed to evaluate the role of CD36 in proliferation and migration of OSCC cells. Methods Human OSCC cell lines HSC‐2, HSC‐3, HSC‐4 and Ca9‐22 were assessed for proliferation by staining with the cell proliferation marker Ki‐67. We also assessed migration activity, and the expression of cell adhesion molecules such as E‐cadherin and β‐catenin and platelet‐derived growth factor receptors (PDGFRs) of CD36‐positive cells. Results CD36‐positive cells showed increased expression of Ki‐67 and migration activity compared with CD36‐negative cells. Moreover, CD36‐positive cells showed reduced expression of E‐cadherin and β‐catenin, whereas the expression of PDGFRs increased compared with that in CD36‐negative cells. Conclusions Our results strongly suggest that CD36 has an important role in facilitating the proliferation and migration activity of OSCC cells, indicating its usefulness in the diagnosis of high‐grade tumour and targeted therapy of oral cancer.